Arnaud Vanden Broeck

Recognized for:
Groundbreaking work in uncovering the intricate processes behind human ribosome assembly, laying the groundwork for treating cancers and diseases related to ribosome dysfunction.

Areas of Research Interest and Expertise:
Ribosome Biogenesis, Gene Expression Regulation, RNA Biology, Biochemistry, Structural Biology

Previous Positions:

BSc, University College of the Province of Liege, Belgium
MSc, University of Liege, Belgium
PhD, University of Strasbourg, France (Advisor: Valerie Lamour)
Postdoctoral Research Associate, The Rockefeller University (Advisor: Sebastian Klinge)

Research Summary:

Arnaud Vanden Broeck, PhD, has made significant strides in understanding how ribosomes—the molecular machines responsible for protein synthesis—are assembled in human cells. Despite the crucial role of ribosomes, much of our previous understanding of eukaryotic ribosome assembly came from studies of yeast. By using advanced techniques like genome editing and cryo-electron microscopy (cryo-EM), Vanden Broeck successfully mapped the structure of key assembly intermediates in human cells. His discoveries shed light on the unique mechanisms and factors involved in human ribosome assembly, offering a new model for how these critical cellular components are formed. This work not only fills longstanding gaps in our knowledge but also lays the groundwork for treating cancers and diseases related to ribosome dysfunction.