Charalampos (Babis) Kalodimos
2011 Regional Award Finalist — Faculty
Current Position:
Professor of Chemistry & Chemical Biology
Institution:
Rutgers University
Discipline:
Chemical Biology
Recognized for: Being the first person to win two key young-investigator awards in the same year; the Biophysical Society's Michael and Kate Barany Award and the Protein Society's award
Areas of Research Interest and Expertise: Protein translocation and secretion, cell signaling and oncogenes, transcription regulation, Type III protein secretion, protein dynamics and allostery
Biography:
- PhD, Bio-organic Chemistry, Institute Curie, Paris, France
- BS, Chemistry-Biochemistry, University of Ioannina, Greece
Charalampos (Babis) Kalodimos studies the molecular and mechanistic basis of a wide range of important biological phenomena with the goal of understanding how central biological processes occur. He is particularly interested in how transcription regulation, protein translocation and secretion, cell signaling, and protein folding take place. In his lab he uses state-of-the-art nuclear magnetic resonance (NMR) spectroscopy that allows the study of the three-dimensional structure of biomolecules in semi-physiological conditions.
Dr. Kalodimos’ use of NMR technology has allowed him to develop a robust research program in protein translocation and secretion, regulation of enzymes by allostery and cell signaling and resulted in a wide variety of publications as well as recognition. Dr. Kalodimos was the 2013 recipient of the Stig Sunner Memorial Award which honors the research contribution of young scientists in the fields of thermodynamics and thermochemistry. He has also been the recipient of the Biophysical Society Young Investigator Award and the Protein Society’s award for his landmark study of the mechanism of protein secretion.
"My main research interests have been focused on the elucidation of the molecular and mechanistic basis of a wide range of important biological phenomena. My current and future efforts are directed towards understanding how central biological processes, such as transcription regulation, protein translocation and secretion, cell signaling, and protein folding take place."
Key Publications:
- T. Saio, X. Guan, P. Rossi, A. Economou & C.G. Kalodimos.Structural basis for protein anti-aggregation activity of the Trigger Factor chaperone. Science, 344, 1250494. 2014
- L. Chen, X. Ai, A. Portaliou, D. Remeta, C. Menetti, A. Economou & C.G. Kalodimos. Substrate-activated conformational switch on chaperones encodes a targeting signal in type III secretion. Cell Reports, 3, 709-715. 2013
- H-S. Tzeng & C.G. Kalodimos.Protein activity regulation by conformational entropy. Nature, 488, 236-240. 2012
Other Honors:
2013 Stig Sunner Memorial Award
2011 Biophysical Society Young Investigator Award
2010 Protein Society’s Award